Neurobiology of Disease Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family
نویسندگان
چکیده
Sabina Anwar,2* Owen Peters,1* Steven Millership,1* Natalia Ninkina,1,4 Natalie Doig,5 Natalie Connor-Robson,1 Sarah Threlfell,2 Gurdeep Kooner,1 Robert M. Deacon,3 David M. Bannerman,3 J. Paul Bolam,5 Sreeganga S. Chandra,6 Stephanie J. Cragg,2 Richard Wade-Martins,2 and Vladimir L. Buchman1 1School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, 2Department of Physiology, Anatomy and Genetics, 3Department of Experimental Psychology, and Oxford Parkinson’s Disease Centre, University of Oxford, Oxford OX1 3QX, United Kingdom, 4Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region, Russian Federation, 5Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson’s Disease Centre, University of Oxford, Oxford OX1 3TH, United Kingdom, and 6Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06536
منابع مشابه
Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism
Synucleins are involved in multiple steps of the neurotransmitter turnover, but the largely normal synaptic function in young adult animals completely lacking synucleins suggests their roles are dispensable for execution of these processes. Instead, they may be utilized for boosting the efficiency of certain molecular mechanisms in presynaptic terminals, with a deficiency of synuclein proteins ...
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Despite numerous evidences for neurotoxicity of overexpressed alpha-synuclein, a protective function was suggested for endogenous alpha-synuclein and other members of the synuclein family. This protective role is most important for and evident in presynaptic terminals, where synucleins are normally accumulated. However, mice lacking synucleins display no adverse phenotype. In particular, no sig...
متن کاملFunctional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.
The synucleins (α, β, and γ) are highly homologous proteins thought to play a role in regulating neurotransmission and are found abundantly in presynaptic terminals. To overcome functional overlap between synuclein proteins and to understand their role in presynaptic signaling from mesostriatal dopaminergic neurons, we produced mice lacking all three members of the synuclein family. The effect ...
متن کاملAbsence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice
Despite numerous evidences for neurotoxicity of overexpressed -synuclein, a protective function was suggested for endogenous -synuclein and other members of the synuclein family. This protective role is most important for and evident in presynaptic terminals, where synucleins are normally accumulated. However, mice lacking synucleins display no adverse phenotype. In particular, no significant c...
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Several neurodegenerative diseases are typified by intraneuronal -synuclein deposits, synaptic dysfunction, and dementia. While even modest -synuclein elevations can be pathologic, the precise cascade of events induced by excessive -synuclein and eventually culminating in synaptotoxicity is unclear. To elucidate this, we developed a quantitative model system to evaluate evolving -synucleininduc...
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تاریخ انتشار 2011